Endocrine Abstracts

Purpose: Glucocorticoid excess causes obesity and hyperphagia (e.g. Cushing syndrome), but the molecular mechanism of glucocorticoid-induced hyperphagia is not fully understood. To clarify this point, we investigated here the phenotype of leptin and Corticotropin-releasing hormone (CRH) double knockout mice (DKO).Methods: Leptin-deficient ob/ob mice were bred with CRH-deficient mice for generation of DKO mice. We examined body weight, food consumption an...